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Pathways Recommended:	Apoptosis

Results for "

mitochondrial apoptosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (153) Mitochondrial Metabolism (27) Mitophagy (1) Adrenergic Receptor (7) Akt (4) Amyloid-β (2) Antibiotic (7) ATP Synthase (1) Autophagy (18) Bacterial (10) Bcl-2 Family (15) Biochemical Assay Reagents (2) Btk (2) Caspase (15) CDK (2) COX (2) Cytochrome P450 (4) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (4) Drug Metabolite (2) EBV (1) EGFR (2) Endogenous Metabolite (8) ERK (2) Eukaryotic Initiation Factor (eIF) (1) Ferroptosis (2) Fungal (10) FXR (1) GSK-3 (1) HDAC (4) HIF/HIF Prolyl-Hydroxylase (1) HIV (9) HSP (1) HSV (1) Imidazoline Receptor (4) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (1) Isotope-Labeled Compounds (6) Keap1-Nrf2 (3) Lipoxygenase (1) MAP3K (1) MAPKAPK2 (MK2) (1) Microtubule/Tubulin (7) MMP (1) Necroptosis (1) NF-κB (9) NO Synthase (1) NOD-like Receptor (NLR) (3) Nucleoside Antimetabolite/Analog (3) Oxidative Phosphorylation (2) P-glycoprotein (1) p38 MAPK (1) PAI-1 (1) Paraptosis (1) Parasite (3) PARP (2) PD-1/PD-L1 (3) PDHK (1) PDK-1 (1) Phosphatase (2) PI3K (6) PKC (1) Potassium Channel (2) PROTACs (1) Proteasome (1) Pyroptosis (1) Pyruvate Kinase (1) RABV (1) Raf (1) Ras (1) Reactive Oxygen Species (41) Reverse Transcriptase (3) Ribosomal S6 Kinase (RSK) (1) ROS Kinase (2) Sirtuin (2) Sodium Channel (1) STAT (1) Toll-like Receptor (TLR) (1) Topoisomerase (8) TrxR (1) Tyrosinase (1) VEGFR (1) β-catenin (1)
By Research Areas:	Cancer (140) Cardiovascular Disease (14) Endocrinology (2) Infection (35) Inflammation/Immunology (19) Metabolic Disease (5) Neurological Disease (13)

By Targets:

Apoptosis (153)

Mitochondrial Metabolism (27)

Mitophagy (1)

Adrenergic Receptor (7)

Akt (4)

Amyloid-β (2)

Antibiotic (7)

ATP Synthase (1)

Autophagy (18)

Bacterial (10)

Bcl-2 Family (15)

Biochemical Assay Reagents (2)

Btk (2)

Caspase (15)

CDK (2)

COX (2)

Cytochrome P450 (4)

DNA Alkylator/Crosslinker (2)

DNA/RNA Synthesis (4)

Drug Metabolite (2)

EBV (1)

EGFR (2)

Endogenous Metabolite (8)

ERK (2)

Eukaryotic Initiation Factor (eIF) (1)

Ferroptosis (2)

Fungal (10)

FXR (1)

GSK-3 (1)

HDAC (4)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (9)

HSP (1)

HSV (1)

Imidazoline Receptor (4)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Influenza Virus (1)

Isotope-Labeled Compounds (6)

Keap1-Nrf2 (3)

Lipoxygenase (1)

MAP3K (1)

MAPKAPK2 (MK2) (1)

Microtubule/Tubulin (7)

MMP (1)

Necroptosis (1)

NF-κB (9)

NO Synthase (1)

NOD-like Receptor (NLR) (3)

Nucleoside Antimetabolite/Analog (3)

Oxidative Phosphorylation (2)

P-glycoprotein (1)

p38 MAPK (1)

PAI-1 (1)

Paraptosis (1)

Parasite (3)

PARP (2)

PD-1/PD-L1 (3)

PDHK (1)

PDK-1 (1)

Phosphatase (2)

PI3K (6)

PKC (1)

Potassium Channel (2)

PROTACs (1)

Proteasome (1)

Pyroptosis (1)

Pyruvate Kinase (1)

RABV (1)

Raf (1)

Ras (1)

Reactive Oxygen Species (41)

Reverse Transcriptase (3)

Ribosomal S6 Kinase (RSK) (1)

ROS Kinase (2)

Sirtuin (2)

Sodium Channel (1)

STAT (1)

Toll-like Receptor (TLR) (1)

Topoisomerase (8)

TrxR (1)

Tyrosinase (1)

VEGFR (1)

β-catenin (1)

By Research Areas:

Cancer (140)

Cardiovascular Disease (14)

Endocrinology (2)

Infection (35)

Inflammation/Immunology (19)

Metabolic Disease (5)

Neurological Disease (13)

190

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Mitochondrial Metabolism Apoptosis Mitophagy SNIPERs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15453

Devimistat 5+ Cited Publications CPI-613	Apoptosis Mitochondrial Metabolism	Cancer
Devimistat (CPI-613) is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce *apoptosis* in various cancer cells .

HY-108547

Alexidine dihydrochloride	Fungal Apoptosis	Infection
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial *apoptosis*. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens .

HY-N7063

Nerol	Reactive Oxygen Species Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite	Infection
Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-147897

Apoptosis inducer 9	Apoptosis
Apoptosis inducer 9 induces *apoptosis* with IC₅₀ value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents .

HY-125612

Artonin E 5'-Hydroxymorusin	Apoptosis	Cancer
Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces *apoptosis* and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research .

HY-161332

Antitumor agent-143	Ferroptosis Pyroptosis Apoptosis Reactive Oxygen Species	Cancer
Antitumor agent-143 (compound 2c) is an antitumor agent that blocks cell proliferation of A549 cells during the S phase and induces an early *apoptosis. Antitumor agent-143 induces cell death via ferroptosis, apoptosis* by a ROS-mediated mitochondrial dysfunction pathway and GSDMD-mediated pyroptosis .

HY-N9802

n-Butyl-β-D-fructofuranoside	Apoptosis Bcl-2 Family	Cancer
n-Butyl-β-D-fructofuranoside could be isolated from kangaisan. n-Butyl-β-D-fructofuranoside induces apoptosis through the mitochondrial pathway. n-Butyl-β-D-fructofuranoside can be used for cancer research .

HY-N7063R

Nerol (Standard)	Reactive Oxygen Species Endogenous Metabolite Fungal Mitochondrial Metabolism Apoptosis	Infection
Nerol (Standard) is the analytical standard of Nerol. This product is intended for research and analytical applications. Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-132173

GL0388	Bcl-2 Family	Cancer
GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC₅₀s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated *apoptosis*. GL0388 suppresses breast cancer xenograft tumor growth in vivo .

HY-144797

Tubulin inhibitor 22	Microtubule/Tubulin	Cancer
Tubulin inhibitor 22 (compound 4c) is a potent inhibitor of tubulin with anti-angiogenesis and anti-cancer properties. Tubulin inhibitor 22 arrests MGC-803 cell cycle at G2/M phase. Tubulin inhibitor 22 dose-dependently causes Caspase-induced *apoptosis* of MGC-803 cells through mitochondrial dysfunction .

HY-103661

BI-6C9	Mitochondrial Metabolism Apoptosis	Neurological Disease
BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .

HY-B0849

Azoxystrobin	Fungal Reactive Oxygen Species Apoptosis Bacterial Phosphatase	Infection
Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell *apoptosis* .

HY-114520

TT01001	Mitochondrial Metabolism Apoptosis Reactive Oxygen Species	Neurological Disease Metabolic Disease
TT01001 is a potent and orally active mitoNEET ligand. TT01001 reduces oxidative stress injury and neuronal *apoptosis* by improving mitochondrial dysfunction. TT01001 improves type II diabetes without causing weight gain .

HY-N6033

Ferruginol (+)-Ferruginol	EBV HSV Apoptosis	Infection Cardiovascular Disease Neurological Disease Cancer
Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial *apoptosis*. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities .

HY-120079

MSN-125 1 Publications Verification	Bcl-2 Family Apoptosis	Cancer
MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC₅₀ of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity .

HY-120035

DD1	Proteasome Ribosomal S6 Kinase (RSK) Apoptosis	Cancer
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation .

HY-N10091

2,3-Dihydro-3α-methoxynimbolide	Apoptosis	Others
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces *apoptosis* via both mitochondrial and death receptor pathways in AZ521 .

HY-145243

PDPOB	Apoptosis	Others
PDPOB is a phenyl carboxylic acid derivative. PDPOB displays protective roles against OGD/R-evoked multiaspect neuronal deterioration in SH-SY5Y cells, as evidenced by alleviated mitochondrial dysfunction, oxidative stress, and *apoptosis*. PDPOB has the potential for the research of cerebral ischemia .

HY-124113

4'-Bromo-resveratrol 4′‐BR	Sirtuin Apoptosis	Cancer
4'-Bromo-resveratrol is a potent and dual inhibitor Sirtuin-1 and Sirtuin-3. 4'-Bromo-resveratrol inhibits melanoma cell growth through mitochondrial metabolic reprogramming. 4'-Bromo-resveratrol imparts antiproliferative effects in melanoma cells through a metabolic reprogramming and affecting the cell cycle and apoptosis signaling .

HY-157125

PI3Kα-IN-14	PI3K Apoptosis	Cancer
PI3Kα-IN-14 (compound F8) is a selective PI3Kα inhibitor with an IC₅₀ of 0.14 nM. PI3Kα-IN-14 induces a great decrease in mitochondrial membrane which caused cell cycle arrest at G1 phase and *apoptosis* in U87-MG cells. PI3Kα-IN-14 shows significant anti-proliferative activities against three tumor-derived cell lines (PC-3: IC₅₀ of 0.28 μM; HCT-116: IC₅₀ of 0.57 μM; and U87-MG: IC₅₀ of 1.37 μM) .

HY-B0432

Propafenone SA-79	Sodium Channel Adrenergic Receptor Potassium Channel	Cardiovascular Disease Cancer
Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC₅₀=32 nM) . Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC₅₀ values of 4.9 μm and 8.6 μm, respectively . Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce *apoptosis* .

HY-N0492

α-Lipoic Acid 5 Publications Verification Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated *apoptosis* in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated *apoptosis* in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-121222

alpha-Bisabolol	PI3K Apoptosis	Cancer
alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, **mitochondrial apoptosis and inhibition of PI3K/Akt** signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities .

HY-B1756

Rotenone Maximum Cited Publications 54 Publications Verification	Mitochondrial Metabolism Autophagy Apoptosis	Neurological Disease Cancer
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-161267

Mitochondrial respiration-IN-4	Mitochondrial Metabolism Reactive Oxygen Species	Cancer
Mitochondrial respiration-IN-4 (Compound TC11) is a potent mitochondrial respiration inhibitor. Mitochondrial respiration-IN-4 impairs Reactive Oxygen Species (ROS) in and induces *apoptosis* in MCF7 cells .

HY-149222

Apoptosis inducer 12	Apoptosis	Cancer
Apoptosis inducer 12 (Compound 3z) is an *apoptosis* inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer .

HY-B1474

Alexidine
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial *apoptosis* .

HY-149221

Apoptosis inducer 11	Apoptosis	Cancer
Apoptosis inducer 11 (compound 3u) induces *apoptosis* through the mitochondrial pathway. Apoptosis inducer 11 induces a block in G2/M, a strong decrease in S phase in non-Hodgkin lymphoma cell lines .

HY-138301

Miclxin DS37262926	β-catenin	Cancer
Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex .

HY-14943

Darinaparsin ZIO-101; S-Dimethylarsino-glutathione	Apoptosis	Cancer
Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces *apoptosis* in ancer cells, and has anticancer effects .

HY-N6882

Genistein 8-c-glucoside G8CG	Mitochondrial Metabolism Apoptosis	Cancer
Genistein 8-c-glucoside (G8CG) is a glucoside. Genistein 8-c-glucoside induces mitochondrial membrane depolarization and induces *apoptosis* .

HY-125857

Cytochrome C	Biochemical Assay Reagents Apoptosis Reactive Oxygen Species	Metabolic Disease
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II *apoptosis* .

HY-N8617

Trijuganone C	Caspase	Cancer
Trijuganone C, a natural product extracted from Salvia miltiorrhiza, inhibits the proliferation of cancer cells through induction of apoptosis mediated by mitochondrial dysfunction and caspase activation .

HY-N12158

Pipermethystine	Apoptosis	Cancer
Pipermethystine is an alkaloid that can be isolated from the Kava plant. Pipermethystine decreases HepG2 cell cellular ATP levels, mitochondrial membrane potential, and induces *apoptosis* .

HY-B0356

Ciprofloxacin 20+ Cited Publications Bay-09867	Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species	Infection Cancer
Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces *apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial* activity .

HY-B0356B

Ciprofloxacin hydrochloride monohydrate 20+ Cited Publications Bay-09867 hydrochloride monohydrate	Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species	Infection Cancer
Ciprofloxacin (Bay-09867) hydrochloride monohydrate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin hydrochloride monohydrate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin hydrochloride monohydrate has anti-proliferative activity and induces *apoptosis. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial* activity .

HY-B0926

Diatrizoic acid Diatrizoate; Amidotrizoic acid	Apoptosis	Inflammation/Immunology
Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium .

HY-B0926A

Sodium diatrizoate Diatrizoic acid sodium salt; Sodium amidotrizoate	Apoptosis	Inflammation/Immunology
Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium .

HY-17495

Carteolol OPC-1085	Adrenergic Receptor Caspase Bcl-2 Family	Neurological Disease
Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research .

HY-139828

Anticancer agent 14	Apoptosis	Cancer
Anticancer agent 14 is a lead compound (IC₅₀: 0.20 to 0.65 μM) that induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.

HY-121204

Iberverin 3-Methylthiopropyl isothiocyanate	Apoptosis Reactive Oxygen Species	Cancer
Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related *apoptosis* and intracellular reactive oxygen species .

HY-B0356A

Ciprofloxacin monohydrochloride 20+ Cited Publications Bay-09867 monohydrochloride	Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species	Infection Cancer
Ciprofloxacin (Bay-09867) monohydrochloride is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin monohydrochloride induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin monohydrochloride has anti-proliferative activity and induces *apoptosis. Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial* activity .

HY-W040298

Ciprofloxacin lactate Bay-09867 lactate	Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species	Infection Cancer
Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces *apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial* activity .

HY-156109

PDK-IN-2	PDHK Mitochondrial Metabolism	Cancer
PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC₅₀: 68 nM). PDK-IN-2 inhibits the cellular expression of PDK1 and PDK4. PDK-IN-2 enhances mitochondrial bioenergetics, attenuates glycolytic phenotypes, and induces cell *apoptosis* in the mitochondrial pathway. PDK-IN-2 inhibits tumor growth in 4T1 syngeneic mice model .

HY-N0330

Momordin Ic 2 Publications Verification	Apoptosis	Cancer
Momordin Ic is a principal saponin constituent of Kochia scoparia L. Schrad. with anti-cancer bioactivity. Momordin Ic is also a SENP1 Inhibitor. Momordin Ic induces apoptosis through oxidative stress-regulated mitochondrial dysfunction .

HY-N8361

Glycoborinine	HIV Apoptosis	Infection Cancer
Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell *apoptosis* through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells .

HY-126222A

MitoTam iodide, hydriodide	Apoptosis Mitochondrial Metabolism	Cancer
MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes *apoptosis* .

HY-161027

DHP-B	Apoptosis	Cancer
DHP-B possesses anti-cancer activity and induces *apoptosis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial* CPT1A-VDAC1 interaction, leading to increased mitochondrial permeability and reduced oxygen consumption and energy metabolism in CRC cells. DHP-B can be isolated from the plant Peperomia dindygulensis .

HY-N4202

Dihydrorotenone	Mitochondrial Metabolism Apoptosis	Neurological Disease
Dihydrorotenone, a natural pesticide, is a potent *mitochondrial* inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell *apoptosis* by triggering endoplasmic reticulum stress and activating p38 signaling pathway .

Cat. No.	Product Name

HY-L089

Mitochondria-Targeted Compound Library

890 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 890 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

HY-L155

Mitochondrial Toxicity Compound Library

470 compounds

Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.

MCE contains 470 mitochondrial toxic compounds, which can be used as tool compounds for drug development, organ toxicity and disease mechanism research.

HY-L085

Anti-Parkinson's Disease Compound Library

1339 compounds

Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD.

MCE offers a unique collection of 1339 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

HY-L133

Cuproptosis Compound Library

187 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 187 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

HY-P3707

Tumor targeted pro-apoptotic peptide	Apoptosis	Cancer
Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes *apoptosis*, showing anticancer activity in mice .

HY-P2048

MOTS-c (human)	Peptides	Others
MOTS-c (human) is a biological active peptide. (Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome.1-2 Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2 All of these peptides are released into cytosol from mitochondria and associate with increased longevity and cell viability, reduced apoptosis, and other beneficial functions. 1-3 MOTS-c was found to reduce insulin resistance, decrease obesity, and promote homeostasis.)

HY-P5325

Bid BH3 (80-99)	Bcl-2 Family	Others
Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7063

Nerol	Infection Natural Products other families Microorganisms Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields	Reactive Oxygen Species Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite
Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-N9802

n-Butyl-β-D-fructofuranoside	Classification of Application Fields Source classification Campanulaceae Plants Disease Research Fields Lobelia chinensis Lour. Saccharides Monosaccharides Cancer	Apoptosis Bcl-2 Family
n-Butyl-β-D-fructofuranoside could be isolated from kangaisan. n-Butyl-β-D-fructofuranoside induces apoptosis through the mitochondrial pathway. n-Butyl-β-D-fructofuranoside can be used for cancer research .

HY-N0492

α-Lipoic Acid 5 Publications Verification Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated *apoptosis* in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N7063R

Nerol (Standard)	Infection Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields	Reactive Oxygen Species Endogenous Metabolite Fungal Mitochondrial Metabolism Apoptosis
Nerol (Standard) is the analytical standard of Nerol. This product is intended for research and analytical applications. Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-N6033

Ferruginol (+)-Ferruginol	Structural Classification Cupressaceae Terpenoids Diterpenoids Thuja standishii (Gord.) Carr. Plants	EBV HSV Apoptosis
Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial *apoptosis*. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities .

HY-N0492A

α-Lipoic Acid sodium Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated *apoptosis* in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-121222

alpha-Bisabolol	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Cancer	PI3K Apoptosis
alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, **mitochondrial apoptosis and inhibition of PI3K/Akt** signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities .

HY-B1756

Rotenone Maximum Cited Publications 54 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Leguminosae Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Mitochondrial Metabolism Autophagy Apoptosis
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-N6882

Genistein 8-c-glucoside G8CG	Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	Mitochondrial Metabolism Apoptosis
Genistein 8-c-glucoside (G8CG) is a glucoside. Genistein 8-c-glucoside induces mitochondrial membrane depolarization and induces *apoptosis* .

HY-N8617

Trijuganone C	Quinones Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Benzene Quinones Plants Naphthalene Quinones	Caspase
Trijuganone C, a natural product extracted from Salvia miltiorrhiza, inhibits the proliferation of cancer cells through induction of apoptosis mediated by mitochondrial dysfunction and caspase activation .

HY-N12158

Pipermethystine	Structural Classification Alkaloids Other Alkaloids Source classification Piper methysticum Forst Piperaceae Plants	Apoptosis
Pipermethystine is an alkaloid that can be isolated from the Kava plant. Pipermethystine decreases HepG2 cell cellular ATP levels, mitochondrial membrane potential, and induces *apoptosis* .

HY-N0330

Momordin Ic 2 Publications Verification	Kochia scoparia L. Schrad. Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer Chenopodiaceae	Apoptosis
Momordin Ic is a principal saponin constituent of Kochia scoparia L. Schrad. with anti-cancer bioactivity. Momordin Ic is also a SENP1 Inhibitor. Momordin Ic induces apoptosis through oxidative stress-regulated mitochondrial dysfunction .

HY-N8361

Glycoborinine	Structural Classification Alkaloids Source classification Rutaceae Plants Indole Alkaloids Glycosmis arborea	HIV Apoptosis
Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell *apoptosis* through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells .

HY-N4202

Dihydrorotenone	Erycibe ferruginea C. Y. Wu Flavonoids Neurological Disease Classification of Application Fields Isoflavanones Source classification Plants Disease Research Fields Convolvulaceae Biological Pesticide Research Agricultural Research	Mitochondrial Metabolism Apoptosis
Dihydrorotenone, a natural pesticide, is a potent *mitochondrial* inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell *apoptosis* by triggering endoplasmic reticulum stress and activating p38 signaling pathway .

HY-N10313

Dehydrobruceine B	Structural Classification Natural Products Microorganisms Source classification	Bcl-2 Family Keap1-Nrf2 Apoptosis
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce *apoptosis* via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2 .

HY-N7526

Naphthazarin 1 Publications Verification DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone	Quinones Structural Classification other families Source classification Phenols Polyphenols Plants Naphthalene Quinones	Apoptosis
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers *apoptosis* and has anti-tumor effects .

HY-N2858

Alpinumisoflavone acetate	Structural Classification Source classification Coumarins Phenylpropanoids Plants Millettia thonningii (Schumach. & Thonn.) Baker Fabaceae	Apoptosis
Alpinumisoflavone acetate is a anticancer agent. Alpinumisoflavone acetate shows antiproliferative activity. Alpinumisoflavone acetate decreases the expression of phosphorylation of ERK1/2. Alpinumisoflavone acetate induces mitochondrial dysfunction and mitochondria-mediated *Apoptosis*. Alpinumisoflavone acetate has the potential for the research of HCC .

HY-N6949

Juglone 2 Publications Verification 5-Hydroxy-1,4-naphthalenedione	Infection Quinones Structural Classification Classification of Application Fields Anti-aging Juglandaceae Source classification Juglans regia Linn. Plants Naphthalene Quinones Disease Research Fields	Bacterial NF-κB Toll-like Receptor (TLR) Apoptosis
Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces *apoptosis* through the mitochondrial pathway. Juglone has antibacterial and antitumor activity .

HY-N3974

Griffipavixanthone (+)-Griffipavixanthone	Structural Classification Flavonoids Source classification Guttiferae Garcinia schomburgkiana Pierre Plants Biflavones	Apoptosis
Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell *apoptosis* through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC₅₀: 4.58 mM) .

HY-N6779

Patulin 3 Publications Verification Terinin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial Apoptosis Autophagy Antibiotic
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .

HY-N0148A

Rutin hydrate 5+ Cited Publications Rutoside hydrate; Quercetin 3-O-rutinoside hydrate	Flavonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N5001

Euphorbia Factor L2	Classification of Application Fields Terpenoids Gramineae Source classification Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Cancer	Apoptosis
Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces *apoptosis* via a mitochondrial pathway .

HY-N0530

Dryocrassin ABBA Dryocrassin	Infection Structural Classification Classification of Application Fields Dryopteridaceae Source classification Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields	Apoptosis Influenza Virus
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by Caspase .

HY-N11648

Ganoderic acid T1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis Caspase
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces *apoptosis* of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

HY-N1306

Sideroxylin	Infection Eucalyptus saligna Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Myrtaceae Plants Disease Research Fields	Bacterial Reactive Oxygen Species Apoptosis
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against *Staphylococcus aureus. Sideroxylin inhibits ovarian cancer cell proliferation and induces apoptosis, causing DNA fragmentation, depolarization of the mitochondrial* membrane, the generation of reactive oxygen species (ROS) .

HY-N6690

Destruxin B	Infection Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields	Bcl-2 Family Caspase Apoptosis
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells . Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated *apoptosis*, not only in vitro but also in vivo .

HY-N2673

5-Heptadecylresorcinol 5-n-Heptadecylresorcinol; AR-C17	Structural Classification Gramineae Source classification Secale cereale Phenols Polyphenols Plants	Sirtuin
5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and *apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy*. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity .

HY-N0148

Rutin 5+ Cited Publications Rutoside; Quercetin 3-O-rutinoside	Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Sunscreen Leguminosae Phenols Polyphenols Cosmetic Research Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N9933

Tauro-β-muricholic acid TβMCA	Structural Classification Human Gut Microbiota Metabolites Microorganisms Animals Source classification Endogenous metabolite Steroids	FXR Apoptosis
Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC₅₀ = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular *apoptosis* by maintaining the mitochondrial membrane potential .

HY-126679

Apoptolidin	Natural Products Microorganisms Source classification Disease Research Fields Cancer	ATP Synthase Apoptosis
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria . Apoptolidin is a selective mitochondrial F₁F_O ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC₅₀=10-17 ng/ml) but not in normal cells .

HY-N0255

alpha-Hederin α-Hederin	Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Araliaceae	Apoptosis
alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce *apoptosis* of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway .

HY-N7363

Isolongifolene (-)-Isolongifolene	Neurological Disease Classification of Application Fields Terpenoids Sesquiterpenes Source classification Rutaceae Murraya koenigii (L.) Spreng Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of PI3K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties .

HY-N12140

2'-epi-2'-O-Acetylthevetin B GHSC-74	Apocynaceae Structural Classification Polysaccharides Source classification Cerbera manghas Linn. Plants Saccharides	Apoptosis
2'-epi-2'-O-Acetylthevetin B (GHSC-74) is a cardiac glycoside that can be isolated from the seeds of Cerbera manghas L. 2'-epi-2'-O-Acetylthevetin B inhibits cell viability, induces *apoptosis* and loss of mitochondrial membrane potential in HepG2 cells .

HY-N10443

Mammea A/BA	other families Source classification Coumarins Phenylpropanoids Plants Calophyllum brasiliense auct. non Camb.	Parasite Apoptosis Autophagy Reactive Oxygen Species
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce *apoptosis, autophagy* and necrosis. Mammea A/BA can be used for researching chagas disease .

HY-N0256

Hederagenin 1 Publications Verification	Triterpenes Structural Classification Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	COX NF-κB
Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .

HY-N0124

Dioscin 5+ Cited Publications Collettiside III; CCRIS 4123	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Autophagy Apoptosis
Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .

HY-W046353

2-Methoxycinnamaldehyde o-Methoxycinnamaldehyde	Cinnamomum cassia (L.) D. Don Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae Disease Research Fields Cancer	Apoptosis
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .

HY-N3497

Isochamaejasmin	Structural Classification Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Other Flavonoids	NF-κB DNA/RNA Synthesis Parasite Apoptosis
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce *apoptosis* via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM) .

HY-W016409

Ethyl 3,4-dihydroxybenzoate Ethyl protocatechuate	Arachis hypogaea L. Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species NO Synthase Autophagy Apoptosis
Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate protects myocardium by activating NO synthase and generating mitochondrial ROS. Ethyl 3,4-dihydroxybenzoate induces cell autophagy and *apoptosis* in ESCC cells. Ethyl 3,4-dihydroxybenzoate is a collagen synthesis inhibitor and has a bone protecting-effect .

HY-N11439

Albanol B	Structural Classification Natural Products Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	CDK Akt ERK Apoptosis Bacterial
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and *apoptosis. And Albanol B induces mitochondrial* ROS production and increases the phosphorylation levels of AKT and ERK1/2 .

HY-N3584

Paris saponin VII 1 Publications Verification Chonglou Saponin VII	Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N8931

Monomethyl lithospermate Lithospermic acid monomethyl ester	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Akt
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) .

HY-13755

Sulforaphane 30+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

HY-13755A

(R)-Sulforaphane L-Sulforaphane	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species NF-κB
(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses .

HY-N0617

Sanggenon C 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Plants Moraceae Flavanonols Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Morus alba Linn.	Phosphatase ERK NF-κB Apoptosis
Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce *apoptosis* by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .

HY-18980

Rottlerin 5 Publications Verification Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-N10503

Norartocarpetin	Structural Classification Flavonoids Flavones Plants Moraceae	Tyrosinase Ras Raf MAPKAPK2 (MK2) Apoptosis
Norartocarpetin is a tyrosinase inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC₅₀ value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC₅₀ value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated *apoptosis*, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells .

HY-N0484

Liensinine 5+ Cited Publications	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Alkaloid Dimers	Autophagy Mitophagy Apoptosis
Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-N0492R

α-Lipoic Acid (Standard) 5 Publications Verification Thioctic acid (Standard); (±)-α-Lipoic acid (Standard); DL-α-Lipoic acid (Standard)	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated *apoptosis* in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

Cat. No.	Product Name	Chemical Structure

HY-N0492S

α-Lipoic Acid-d5
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

HY-B0849S1

Azoxystrobin-d3
Azoxystrobin-d₃ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis[1].

HY-B0116S

Stavudine-d4
Stavudine-d₄ is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].

HY-B0849S

Azoxystrobin-d4
Azoxystrobin-d₄ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

HY-N6779S

Patulin-13C7
Patulin- ¹³C₇ (Terinin- ¹³C₇) is the ¹³C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .

HY-B1899S

Taurodeoxycholic acid-d5

Taurodeoxycholic acid-d₅is the deuterium labeledTaurodeoxycholic acid(HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

HY-117433S

4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d₄ is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

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